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Sodium Hydroxide → 5-[9-(5-{3-Cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]pentanoic acid

HRID 1514286
ノート
印刷プレビュー

反応式

HRID 1514286 の反応式
[OH-].[Na+].[C:3]([C:5]1[CH:6]=[C:7]([C:15]2[O:19][N:18]=[C:17]([C:20]3[C:30]4[O:29][CH2:28][CH2:27][N:26]([CH2:31][CH2:32][CH2:33][CH2:34][C:35]([O:37]CC)=[O:36])[CH2:25][C:24]=4[CH:23]=[CH:22][CH:21]=3)[N:16]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH:12]([CH3:14])[CH3:13])#[N:4]>C(O)C>[C:3]([C:5]1[CH:6]=[C:7]([C:15]2[O:19][N:18]=[C:17]([C:20]3[C:30]4[O:29][CH2:28][CH2:27][N:26]([CH2:31][CH2:32][CH2:33][CH2:34][C:35]([OH:37])=[O:36])[CH2:25][C:24]=4[CH:23]=[CH:22][CH:21]=3)[N:16]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH:12]([CH3:14])[CH3:13])#[N:4]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 59403540Ethyl 5-[9-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]pentanoate

生成物 1

HCID 441292205-[9-(5-{3-Cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]pentanoic acid収率 30.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

2M sodium hydroxide (0.347 mL, 0.694 mmol) was added to a stirred solution of ethyl 5-[9-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]pentanoate (Preparation 93) (70 mg, 0.139 mmol) in ethanol (5 mL) and the mixture was heated to 60° C. overnight. The reaction mixture was allowed to cool to room temperature and the solvent evaporated. The residue was diluted with water, acidified with 2M hydrochloric acid and extracted with ethyl acetate. The organic phase was washed with water, dried and evaporated to give the product as an off white solid (20 mg).

後処理

  1. temperatureto cool to room temperature
  2. customthe solvent evaporated
  3. additionThe residue was diluted with water
  4. extractionextracted with ethyl acetate
  5. washThe organic phase was washed with water
  6. customdried
  7. customevaporated

出典と根拠

ORDレコード
ord-48cf665a506843c4855abd3e2bf89e9a
出典データセット
uspto-grants-2012_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08222245B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート