Trifluoroacetic acid → HCID 44129294、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:34]=[CH:33][C:20]4[CH2:21][CH2:22][N:23](C(OC(C)(C)C)=O)[CH2:24][CH2:25][C:19]=4[CH:18]=3)[N:13]=2)[CH:5]=[N:6][C:7]=1[O:8][CH:9]([CH3:11])[CH3:10].FC(F)(F)C(O)=O>ClCCl>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:34]=[CH:33][C:20]4[CH2:21][CH2:22][NH:23][CH2:24][CH2:25][C:19]=4[CH:18]=3)[N:13]=2)[CH:5]=[N:6][C:7]=1[O:8][CH:9]([CH3:10])[CH3:11]参加物
4
実験手順
1,1-Dimethylethyl 7-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (Preparation 96) (305 mg, 0.629 mmol) in dichloromethane (2 mL) at room temperature was treated with trifluoroacetic acid (1 ml, 12.98 mmol) and the mixture stirred for 1 hr. The reaction mixture was concentrated and the residue partitioned between 2M NaOH and ethyl acetate. The ethyl acetate extract was washed with brine, dried and concentrated to a colourless gum which slowly crystallized, to give the title compound free base (229 mgs).