Formic Acid → N-(4-chlorophenyl)formamide

HRID 1514357ノート

反応式

HRID 1514357 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH:9](O)=[O:10]>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH:9]=[O:10])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 284Formic AcidHCID 78124-Chloroaniline

生成物 1

HCID 17475N-(4-chlorophenyl)formamide収率 88%

実験手順

4-Chloroaniline (10 g, 78.4 mmol) and formic acid were heated to reflux for 30 minutes. The reaction mixture was concentrated in vacuo. Water was added and basified with sodium carbonate and extracted with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtrated and evaporated to give N-(4-chloro-phenyl)-formamide (10.7 g, 88%).

後処理

  1. temperatureto reflux for 30 minutes
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. additionWater was added
  4. extractionextracted with ethyl acetate
  5. dry with materialThe combined organic phases were dried over magnesium sulphate
  6. filtrationfiltrated
  7. customevaporated

出典と根拠

ORDレコード
ord-2c1aabcd1275451db6168ebd9989e894
出典データセット
uspto-grants-2012_07
特許番号
US08222262B2

反応ノート

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