Sodium Hydroxide → 2-(2,6-Dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid

HRID 1514970ノート

反応式

HRID 1514970 の反応式
C[O:2][C:3]([C:5]1[CH:21]=[CH:20][C:8]2[N:9]=[C:10]([C:12]3[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:19])[O:11][C:7]=2[CH:6]=1)=[O:4].[OH-].[Na+]>CCO>[Cl:19][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=1[C:10]1[O:11][C:7]2[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:21]=[CH:20][C:8]=2[N:9]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 669656572-(2,6-Dichlorophenyl)-benzooxazole-6-carboxylic acid methyl ester

生成物 1

HCID 53271602-(2,6-Dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a solution of 2-(2,6-dichlorophenyl)-benzooxazole-6-carboxylic acid methyl ester (1.6 g) in EtOH (13 mL) was added 4N NaOH aqueous solution (6.2 mL). The reaction was stirred at 80° C. for 0.5 h. The reaction mixture was concentrated, diluted with water, and treated with Et2O. The aqueous layer was acidified with 1N HCl aqueous solution. The precipitate was filtered, washed with water, and dried in vacuo to give 2-(2,6-dichloro-phenyl)-benzooxazole-6-carboxylic acid as a white solid: MS (m/z) 308.0 (M+1).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additiondiluted with water
  3. additiontreated with Et2O
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-a6e1d48bb0984e01833eba7bdc030ddc
出典データセット
uspto-grants-2012_07
特許番号
US08222248B2

反応ノート

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