Water → HCID 58320692、化合物

HRID 1515369ノート

反応式

HRID 1515369 の反応式
[CH3:1][CH2:2][C:3]([C:5](Cl)=[O:6])=[O:4].C=[C:9]1[O:13][CH2:12]C[O:10]1.N1[CH:19]=[CH:18]C=CC=1.[OH2:20]>C(Cl)Cl>[O:13]1[CH2:12]/[C:1](=[CH:2]\[C:3](=[O:4])[C:5]([O:6][CH2:18][CH3:19])=[O:20])/[O:10][CH2:9]1

参加物

6

反応物 4

HCID 962WaterHCID 1049PyridineHCID 11007880Butanoyl chloride, 2-oxo-HCID 117684952-Methylene-1,3-dioxolane

生成物 1

HCID 58320692HCID 58320692、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
5 °C

実験手順

The solution of ethyloxalyl chloride (10.3 g, 75.5 mmol) in CH2Cl2 (10 mL) was added at 0° C. to the solution of methylene dioxolane (6.5 g, 75.5 mmol) and pyridine (6.3 g, 80 mmol) in CH2Cl (80 mL). The reaction mixture was stirred for 10 hours at 5° C. and diluted with 200 ml of water. The product was extracted with 200 ml of hexane, the solution of hexane was dried with MgSO4 and concentrated by evaporation. This gave 11.9 g (85%) of the product, b.p. 106-110° C./0.5 mmHg.

後処理

  1. extractionThe product was extracted with 200 ml of hexane
  2. dry with materialthe solution of hexane was dried with MgSO4
  3. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-a5537c31416c4e8abd352e75baddf41d
出典データセット
uspto-grants-2012_07
特許番号
US08222435B2

反応ノート

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