4-Bromo-2-ethenyl-1-fluorobenzene → 4-Bromo-2-ethyl-1-fluorobenzene

HRID 1515565ノート

反応式

HRID 1515565 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([CH:9]=[CH2:10])[CH:3]=1.[H][H]>CCOC(C)=O.[Pd]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([CH2:9][CH3:10])[CH:3]=1

参加物

5

反応物 2

HCID 219339834-Bromo-2-ethenyl-1-fluorobenzeneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 226410254-Bromo-2-ethyl-1-fluorobenzene収率 62%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

4-Bromo-1-fluoro-2-vinylbenzene (470 mg) was hydrogenated in EtOAc with 10% Pd/C (100 mg) with a hydrogen balloon for 2.0 h. The Pd/C was removed by filtration. The filtrate was condensed to give 95A (290 mg, 62% yield) as an orange oil. 1H NMR (400 MHz, CDCl3) δ ppm 1.22 (t, J=6.81 Hz, 3H) 2.63 (d, J=7.03 Hz, 2H) 6.88 (t, J=8.57 Hz, 1H) 7.25 (s, 1H) 7.32 (d, J=4.39 Hz, 1H).

後処理

  1. customThe Pd/C was removed by filtration
  2. customcondensed

出典と根拠

ORDレコード
ord-d5e91bbeeaa241e8854949b9001d98f9
出典データセット
uspto-grants-2012_07
特許番号
US08222453B2

反応ノート

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