(5-[(1,1-Dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate → {5-[(1,1-Dimethylethyl)thio]-4-oxo-1,4-dihydro-2-pyridinyl}methyl acetate
反応式
[C:1]([O:4][CH2:5][C:6]1[CH:11]=[C:10]([O:12]CC2C=CC=CC=2)[C:9]([S:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:8][N:7]=1)(=[O:3])[CH3:2]>O1CCOCC1.O.[Pd]>[C:1]([O:4][CH2:5][C:6]1[NH:7][CH:8]=[C:9]([S:20][C:21]([CH3:24])([CH3:23])[CH3:22])[C:10](=[O:12])[CH:11]=1)(=[O:3])[CH3:2]参加物
4
実験手順
A solution of (5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate (6 g) in 1,4-dioxane/water (100 ml/50 ml) was hydrogenated at atmospheric pressure with 10% palladium on charcol (7 g) overnight. Filtration and evaporation afforded a white solid (4.46 g, 95%).
後処理
- filtrationFiltration and evaporation
出典と根拠
- ORDレコード
- ord-50588ac79e3c4fe893f88290c98fec15
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732460B2
反応ノート
読み込み中…