Hydrazine hydrate (1:1) → HCID 178514432、化合物
反応式
C[O:2][C:3]([C@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:6]1)=O.O.[NH2:19][NH2:20]>>[O:11]([C@H:8]1[CH2:9][CH2:10][C@H:5]([C:3]([NH:19][NH2:20])=[O:2])[CH2:6][CH2:7]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1参加物
3
反応条件
- 温度
- 120 °C
実験手順
A mixture of trans-4-phenoxy-cyclohexanecarboxylic acid methyl ester (1.07 g, 4.57 mmol) and hydrazine hydrate (0.22 g, 4.48 mmol) was heated at 120° C. for 4 h. After cooling to room temperature the reaction mixture was concentrated in vacuo to give the crude title compound as white solid in quantitative yield, which was used in the next step without further purification.
後処理
- temperatureAfter cooling to room temperature the reaction mixture
- concentrationwas concentrated in vacuo
出典と根拠
- ORDレコード
- ord-c8e9c8d73b7c4d04afb76377e71d9390
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08227458B2
反応ノート
読み込み中…