N,6-Dimethyl-5-nitropyridin-2-amine → HCID 55285663、化合物
反応式
[CH3:1][NH:2][C:3]1[N:8]=[C:7]([CH3:9])[C:6]([N+:10]([O-])=O)=[CH:5][CH:4]=1.[H][H]>CO.[Pd]>[CH3:1][NH:2][C:3]1[N:8]=[C:7]([CH3:9])[C:6]([NH2:10])=[CH:5][CH:4]=1参加物
5
実験手順
A suspension of 0.4 g (2.39 mmol) of 6-methylamino-2-methyl-3-nitropyridine (Prace Naukowe Akedimii Ekonomicznej imienia Oskara Langego we Wroclawiu (1988), 435, 119-28) and 0.1 g of 10% palladium-on-charcoal in 50 ml of methanol is stirred at 20° C. for 6 hours under 4 atmospheres of hydrogen. The reaction mixture is subsequently filtered through a celite plug and then concentrated under reduced pressure. 0.33 g of the expected product is thus isolated in the form of an oil which will be used as is in the continuation of the synthesis.
後処理
- filtrationThe reaction mixture is subsequently filtered through a celite plug
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-b642c057e7aa4701a3d5057d2191e32f
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08227489B2
反応ノート
読み込み中…