Trifluoroacetic acid → N-(2-Aminoacetyl)-4-(2-butyl-4-chloro-5-formyl-imidazol-1-ylmethyl)benzenesulfonamide
反応式
C(OC(=O)[NH:7][CH2:8][C:9]([NH:11][S:12]([C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N:22]2[C:26]([CH:27]=[O:28])=[C:25]([Cl:29])[N:24]=[C:23]2[CH2:30][CH2:31][CH2:32][CH3:33])=[CH:17][CH:16]=1)(=[O:14])=[O:13])=[O:10])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][CH2:8][C:9]([NH:11][S:12]([C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N:22]2[C:26]([CH:27]=[O:28])=[C:25]([Cl:29])[N:24]=[C:23]2[CH2:30][CH2:31][CH2:32][CH3:33])=[CH:17][CH:16]=1)(=[O:13])=[O:14])=[O:10]参加物
4
実験手順
Intermediate (2d) (5.6 g) was dissolved into 20 mL 30% TFA:DCM and stirred at room temperature for 2 hours. The mixture was concentrated under reduced pressure to yield the title compound as an oil in a quantitative yield. MS m/z: [M+H+] calcd for C17H21ClN4O4S 413.1; found 413.3.