Tetrahydrofuran → (4S)-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethoxy)phenyl]methyl}-7-isopropyl-3,4-dihydrospiro[chromen-2,1'-cyclobutan]-4-ol

HRID 1516747ノート

反応式

HRID 1516747 の反応式
N[C@@H]1C2C(=CC=CC=2)C[C@@H]1O.O1CCCC1.[F:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[C:36]([CH:37]([F:49])[C:38]3[CH:43]=[CH:42][C:41]([O:44][C:45]([F:48])([F:47])[F:46])=[CH:40][CH:39]=3)=[C:35]([CH:50]([CH3:52])[CH3:51])[CH:34]=[C:33]3[C:25]=2[C:26](=[O:53])[CH2:27][C:28]2([O:32]3)[CH2:31][CH2:30][CH2:29]2)=[CH:20][CH:19]=1>CO>[F:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[C:36]([CH:37]([F:49])[C:38]3[CH:43]=[CH:42][C:41]([O:44][C:45]([F:47])([F:48])[F:46])=[CH:40][CH:39]=3)=[C:35]([CH:50]([CH3:51])[CH3:52])[CH:34]=[C:33]3[C:25]=2[C@@H:26]([OH:53])[CH2:27][C:28]2([O:32]3)[CH2:31][CH2:30][CH2:29]2)=[CH:22][CH:23]=1

参加物

5

反応物 3

HCID 8028Tetrahydrofuran2 回HCID 2725045(1R,2S)-(+)-cis-1-Amino-2-indanolHCID 580029745-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one

生成物 1

HCID 58002989(4S)-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethoxy)phenyl]methyl}-7-isopropyl-3,4-dihydrospiro[chromen-2,1'-cyclobutan]-4-ol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Under argon, 0.6 mg (0.004 mmol) of (1R,2S)-1-aminoindan-2-ol is dissolved in 0.5 ml of abs. tetrahydrofuran, 27.5 μl (0.15 mmol) of borane/N,N-diethylaniline complex are added and the mixture is stirred at room temperature for 30 min. After this time, 20 mg (0.04 mmol) of 5-(4-fluorophenyl)-6-{fluoro[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1′-cyclobutan]-4(3H)-one (Example 59A), dissolved in 1 ml of abs. tetrahydrofuran, are then added at room temperature over a period of 10 min, and the mixture is then stirred at room temperature overnight. 3 ml of methanol are added, and the mixture is stirred for 15 min and then concentrated to dryness. The residue is taken up in ethyl acetate and washed twice with 1 N hydrochloric acid, twice with saturated sodium bicarbonate solution and twice with saturated sodium chloride solution. The organic phase is dried over sodium sulfate, filtered and concentrated. The crude product is purified by thick-layer chromatography (mobile phase: cyclohexane→cyclohexane/ethyl acetate 5:1). This is followed by further purification by preparative HPLC. This gives 5.3 mg (26% of theory) of the title compound as a mixture of diastereomers.

後処理

  1. stirringthe mixture is then stirred at room temperature overnight
  2. stirringthe mixture is stirred for 15 min
  3. concentrationconcentrated to dryness
  4. washwashed twice with 1 N hydrochloric acid, twice with saturated sodium bicarbonate solution and twice with saturated sodium chloride solution
  5. dry with materialThe organic phase is dried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customThe crude product is purified by thick-layer chromatography (mobile phase: cyclohexane→cyclohexane/ethyl acetate 5:1)
  9. customThis is followed by further purification by preparative HPLC
  10. additionThis gives 5.3 mg (26% of theory) of the title compound as a mixture of diastereomers

出典と根拠

ORDレコード
ord-1233189df13c42dcba432c879d347a28
出典データセット
uspto-grants-2012_07
特許番号
US08227511B2

反応ノート

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