Chloroform → HCID 67382660、化合物

HRID 1517215ノート

反応式

HRID 1517215 の反応式
[Cl-].[CH2:2]([N+:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[CH3:24][CH2:25][N:26]1[C:32](=[O:33])[C:30](=[O:31])[N:29]([C:34]([NH:36][C@@H:37]([C:44]([NH:46][C@@H:47]2[C:50](=[O:51])[N:49]3[C@@H:52]([C:57]([O-:59])=[O:58])[C:53]([CH3:56])([CH3:55])[S:54][C@H:48]23)=[O:45])[C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)=[O:35])[CH2:28][CH2:27]1.[Na+].C(Cl)(Cl)Cl>O>[CH2:2]([N+:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[CH3:24][CH2:25][N:26]1[C:32](=[O:33])[C:30](=[O:31])[N:29]([C:34]([NH:36][C@@H:37]([C:44]([NH:46][C@@H:47]2[C:50](=[O:51])[N:49]3[C@@H:52]([C:57]([OH:59])=[O:58])[C:53]([CH3:55])([CH3:56])[S:54][C@H:48]23)=[O:45])[C:38]2[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=2)=[O:35])[CH2:28][CH2:27]1

参加物

5

反応物 3

HCID 6212ChloroformHCID 31239Cetylpyridinium ChlorideHCID 23666879Piperacillin sodium

生成物 1

HCID 67382660HCID 67382660、化合物収率 58.66%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Hexadecylpyridinium chloride (0.001 mol) was dissolved in 60 mL of distilled water by gentle heating and stirring. Sodium piperacillin (0.001 mol) was dissolved in 60 mL of distilled water by gentle heating and stirring. The two solutions were combined and the reaction mixture was heated and stirred for 30 minutes. The reaction mixture cooled to room temperature, and then 60 mL of chloroform was added. The reaction mixture was stirred for an additional 30 minutes. The two phases were separated and the chloroform phase was washed several times with cool distilled water to remove any inorganic salt. The presence of chloride anions was monitored by silver nitrate test. A rotary evaporator removed the chloroform and a soft orange solid was obtained in 58.66% yield. Melting point (hot plate apparatus)=30-40° C.

後処理

  1. temperatureby gentle heating
  2. temperatureby gentle heating
  3. stirringstirring
  4. temperaturethe reaction mixture was heated
  5. stirringstirred for 30 minutes
  6. stirringThe reaction mixture was stirred for an additional 30 minutes
  7. customThe two phases were separated
  8. washthe chloroform phase was washed several times
  9. temperaturewith cool
  10. distillationdistilled water
  11. customto remove any inorganic salt
  12. customA rotary evaporator
  13. customremoved the chloroform
  14. customa soft orange solid was obtained in 58.66% yield
  15. customMelting point (hot plate apparatus)=30-40° C.

出典と根拠

ORDレコード
ord-2a17d5587a3a480fb1b70b8e0019d44d
出典データセット
uspto-grants-2012_07
特許番号
US08232265B2

反応ノート

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