Sodium Chloride → 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonic acid;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

HRID 1517223ノート

反応式

HRID 1517223 の反応式
[CH3:1][CH2:2][N:3]([CH2:6][C:7]([NH:9][C:10]1[C:11]([CH3:17])=[CH:12][CH:13]=[CH:14][C:15]=1[CH3:16])=[O:8])[CH2:4][CH3:5].Cl.[Na].[CH3:20][CH2:21][CH2:22][CH2:23][CH:24]([CH2:27][O:28][C:29]([CH2:31][CH:32]([S:44]([OH:47])(=[O:46])=[O:45])[C:33]([O:35][CH2:36][CH:37]([CH2:40][CH2:41][CH2:42][CH3:43])[CH2:38][CH3:39])=[O:34])=[O:30])[CH2:25][CH3:26].[Na+].[Cl-].C(Cl)(Cl)Cl>CO>[CH3:5][CH2:4][N:3]([CH2:6][C:7]([NH:9][C:10]1[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:17])=[O:8])[CH2:2][CH3:1].[CH3:20][CH2:21][CH2:22][CH2:23][CH:24]([CH2:27][O:28][C:29]([CH2:31][CH:32]([S:44]([OH:47])(=[O:46])=[O:45])[C:33]([O:35][CH2:36][CH:37]([CH2:40][CH2:41][CH2:42][CH3:43])[CH2:38][CH3:39])=[O:34])=[O:30])[CH2:25][CH3:26]

参加物

6

反応物 4

HCID 5234Sodium Chloride2 回HCID 6212Chloroform2 回HCID 6314Lidocaine HydrochlorideHCID 9955175Sodium docusate

生成物 1

HCID 177558781,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonic acid;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Lidocaine hydrochloride (0.0188 mol) was dissolved in 50 mL methanol and sodium docusate [bis(2-ethylhexyl)sulfosuccinate sodium salt] (0.0188 mol) was dissolved in 50 mL. The two solutions were combined and stirred for two hours, during this time a white precipitate (NaCl) formed. The methanol was removed by rotary evaporation which leaves a white sticky solid. To this solid, 150 mL of chloroform was added. A portion of the product dissolved the chloroform while the byproduct (NaCl) remained as a suspended solid. The NaCl was removed by filitration, and the solvent was removed by rotary evaporation. The product, lidocaine docusate, is a colorless syrup and is dried under high vacuum. 1H and 13C NMR (CDCl3) were obtained.

後処理

  1. customformed
  2. customThe methanol was removed by rotary evaporation which
  3. customleaves a white sticky solid
  4. customThe NaCl was removed by filitration
  5. customthe solvent was removed by rotary evaporation
  6. customis dried under high vacuum
  7. custom1H and 13C NMR (CDCl3) were obtained

出典と根拠

ORDレコード
ord-78cd1f5ba64544ea9ff536906c2385a6
出典データセット
uspto-grants-2012_07
特許番号
US08232265B2

反応ノート

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