Aluminium lithium hydride → HCID 178491757、化合物
反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[NH:20][C:19]3[C:21]([C:25](OC)=[O:26])=[CH:22][CH:23]=[CH:24][C:18]=3[N:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:29])[CH:4]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[OH:26][CH2:25][C:21]1[C:19]2[NH:20][C:16]([CH2:15][N:13]([CH3:14])[S:10]([C:6]3[C:5]([CH3:29])=[CH:4][C:3]([O:2][CH3:1])=[CH:8][C:7]=3[CH3:9])(=[O:12])=[O:11])=[N:17][C:18]=2[CH:24]=[CH:23][CH:22]=1参加物
4
実験手順
A solution of methyl 2-((4-methoxy-N,2,6-trimethylphenylsulfonamido)methyl)-1H-benzo[d]imidazole-7-carboxylate (2.40 mmol, 1.0 eq.) was added dropwise to a suspension of LAH (5.28 mmol, 2.2 eq.) in abs. THF (5 ml) under N2 at 0° C. When the addition had ended, the reaction mixture was warmed to room temperature and stirred for 2 h. The reaction mixture was then quenched with THF/water (9:1; 3 ml), while cooling, and filtered over Celite. The filtrate was concentrated to dryness and the crude product was purified by column chromatography over silica gel to obtain the desired product. Yield: 75%