Triethylamine → HCID 66669764、化合物

HRID 1517902ノート

反応式

HRID 1517902 の反応式
[OH:1][CH:2]1[C:6]2([CH2:8][CH2:7]2)[CH2:5][NH:4][CH2:3]1.Br[CH2:10][CH2:11][CH2:12][OH:13].CCN(CC)CC>C1COCC1>[OH:1][CH:2]1[C:6]2([CH2:8][CH2:7]2)[CH2:5][N:4]([CH2:10][CH2:11][CH2:12][OH:13])[CH2:3]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 123083-Bromo-1-propanolHCID 167382865-Azaspiro[2.4]heptan-7-ol

生成物 1

HCID 66669764HCID 66669764、化合物収率 60.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 7-hydroxy-5-azaspiro[2.4]heptane (1.23 g, 11.0 mmol) in THF (40 mL) was added 3-bromopropanol (2.3 g, 16.65 mmol) and Et3N (2.24 g, 22.2 mmol). The reaction mixture was stirred at rt for 12 hrs and then concentrated in vacuo. The residue was purified by a silica gel column chromatography (100:50:2(v/v/v)EtOAc/CH3OH/Et3N) to afford the desired compound as orange oil (1.14 g, 60%).

後処理

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by a silica gel column chromatography (100:50:2(v/v/v)EtOAc/CH3OH/Et3N)

出典と根拠

ORDレコード
ord-a66fa061c5c44656a6f556dec09b07f1
出典データセット
uspto-grants-2012_07
特許番号
US08232294B2

反応ノート

読み込み中…