1-Phenylpiperazine → 3-(4-Methylpiperazin-1-yl)phenol

HRID 1518372

反応式

HRID 1518372 の反応式
S1C2C=CC=CC=2N=C1N(COCC[Si](C)(C)C)C(C1C=CC=C2C=1CN(C1SC([CH2:32][N:33]3[CH2:38][CH2:37][N:36]([C:39]4[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=4)[CH2:35][CH2:34]3)=C(C(OC)=O)N=1)CC2)=O.C(C1SC(N2CCC3C(=C(C(=O)/N=C4/SC5C=CC=CC=5N/4COCC[Si](C)(C)C)C=CC=3)C2)=NC=1C(OC)=O)=[O:54].C1C=CC(N2CCNCC2)=CC=1.N1(C2C=C(O)C=CC=2)CCNCC1>>[CH3:32][N:33]1[CH2:38][CH2:37][N:36]([C:39]2[CH:44]=[C:43]([OH:54])[CH:42]=[CH:41][CH:40]=2)[CH2:35][CH2:34]1

参加物

5

反応物 4

HCID 70961-PhenylpiperazineHCID 27365971-(3-Hydroxyphenyl)piperazineHCID 59447670methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-((4-phenylpiperazin-1-yl)methyl)thiazole-4-carboxylateHCID 178499107HCID 178499107、化合物

生成物 1

HCID 110114553-(4-Methylpiperazin-1-yl)phenol

実験手順

Compound 87A was prepared in a similar manner to the synthesis of compound 62A by substituting compound 45C and phenylpiperazine with paraformahyde and 3-(piperazin-1-yl)phenol, respectively: 1H NMR (DMSO-d6): δ 9.07 (s, 1H), 6.94-6.98 (m, 1H), 6.36 (d, J=8.13, 2.4 Hz, 2H), 8.28-8.29 (m, 1H), 6.18-6.21 (m, 1H), 3.04-3.07 (m, 4H), 2.41-2.43 (m, 4H), 2.21 (s, 3H). ESI (+)/MS: 193 (M+H)+.

出典と根拠

ORDレコード
ord-1db435a09d5f493fa91f3a03b4cfc019
出典データセット
uspto-grants-2012_07
特許番号
US08232273B2

関連ノート

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