Potassium Carbonate → 6-Ethynylnaphthalen-2-ol

HRID 1518405

反応式

HRID 1518405 の反応式
C[Si]([C:5]#[C:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([OH:17])[CH:11]=[CH:10]2)(C)C.C([O-])([O-])=O.[K+].[K+]>CO.C1COCC1.C(OCC)(=O)C>[C:6]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([OH:17])[CH:11]=[CH:10]2)#[CH:5]

参加物

6

反応物 2

HCID 11430Potassium CarbonateHCID 594475526-((Trimethylsilyl)ethynyl)naphthalen-2-ol

生成物 1

HCID 190817686-Ethynylnaphthalen-2-ol

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Compound 110A (770 mg, 3.20 mmol) in MeOH (5 ml) and THF (10 ml) was treated with K2CO3 (885 mg, 6.41 mmol) at room temperature for 3 h. The reaction was diluted with ethyl acetate and washed with water. The organic layer was concentrated and the residue was purified by flash chromatography, eluted with DCM to provide the compound 110B.

後処理

  1. washwashed with water
  2. concentrationThe organic layer was concentrated
  3. customthe residue was purified by flash chromatography
  4. washeluted with DCM

出典と根拠

ORDレコード
ord-b26daf207e0a4777895a4cc24c021b56
出典データセット
uspto-grants-2012_07
特許番号
US08232273B2

関連ノート

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