Oxalyl chloride → 5-Bromo-2-chloro-3-pyridinecarbonyl chloride
反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5]([Cl:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].C(Cl)(=O)C([Cl:15])=O>C(Cl)Cl.CN(C)C=O>[Br:1][C:2]1[CH:10]=[C:6]([C:7]([Cl:15])=[O:8])[C:5]([Cl:11])=[N:4][CH:3]=1参加物
5
実験手順
To a slurry of 5-bromo-2-chloronicotinic acid (2.063 g, 8.725 mmol) in methylene chloride (20 mL) was slowly added oxalyl chloride (1.11 g, 8.725 mmol) followed by the addition of dimethylformamide (5 drops). After 4H the mixture was concentrated in vacuo to provide 2.21 g of 5-bromo-2-chloropyridine-3-carbonyl chloride as a light brown solid, which was used as is in the next reaction.
後処理
- concentrationAfter 4H the mixture was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-6c60691e92624cf885feaaa13f5d2984
- 出典データセット
- uspto-grants-2012_07
- 特許番号
- US08232406B2
反応ノート
読み込み中…