Water → Ethyl 3-(4-cyano-3-methoxyphenyl)oxirane-2-carboxylate

HRID 1519573ノート

反応式

HRID 1519573 の反応式
[CH:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([O:11][CH3:12])[CH:4]=1)=[O:2].[CH2:13]([O:15][C:16](=[O:19])[CH2:17]Cl)[CH3:14].CC[O-].[Na+].O>C1C=CC=CC=1.C(O)C>[C:7]([C:6]1[CH:9]=[CH:10][C:3]([CH:1]2[O:2][CH:17]2[C:16]([O:15][CH2:13][CH3:14])=[O:19])=[CH:4][C:5]=1[O:11][CH3:12])#[N:8]

参加物

7

反応物 4

HCID 962WaterHCID 7751Ethyl chloroacetateHCID 2723922Sodium ethoxideHCID 600485344-Formyl-2-methoxybenzonitrile

生成物 1

HCID 86694471Ethyl 3-(4-cyano-3-methoxyphenyl)oxirane-2-carboxylate

試薬・触媒・溶媒 2

HCID 241Benzene溶媒HCID 702Ethanol溶媒

実験手順

A mixture of 4-formyl-2-methoxybenzonitrile (383 mg, 2.38 mmol) and chloroacetic acid ethyl ester (291 mg, 2.38 mmol) were dissolved in 10 mL of dry benzene. Freshly prepared EtONa (3.09 mmol) in 2.5 mL of ethanol was added, and the mixture were stirred at room temperature for 2 hours. The mixture was added water, then extracted with EtOAc. The organic layers were dried over Na2SO4 and concentrated to afford ethyl 3-(4-cyano-3-methoxyphenyl)oxirane-2-carboxylate. MS m/z: 248 (M+1)+.

後処理

  1. extractionextracted with EtOAc
  2. dry with materialThe organic layers were dried over Na2SO4
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-6c84f276db3e44a0a421c23da3162514
出典データセット
uspto-grants-2015_07
特許番号
US09073882B2

反応ノート

読み込み中…