N-bromobutanimide → 5-Fluoro-2-iodo-4-trifluoromethyl-phenylamine

HRID 1519893ノート

反応式

HRID 1519893 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10])[NH2:5].C1C(=O)N([Br:20])C(=O)C1>C(Cl)Cl>[Br:20][C:6]1[CH:7]=[C:8]([C:9]([F:10])([F:11])[F:12])[C:2]([F:1])=[CH:3][C:4]=1[NH2:5]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 27359144-Amino-2-fluorobenzotrifluoride

生成物 1

HCID 687591875-Fluoro-2-iodo-4-trifluoromethyl-phenylamine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a stirring mixture of 3-fluoro-4-(trifluoromethyl)aniline (1.5 g) in DCM (12 mL) at room temperature was added dropwise a solution of NBS (1.5 g) in DCM (24 mL) over 15 min. The reaction mixture was stirred at rt for 1.5 h. The product mixture was concentrated under reduced pressure to one half of its original volumn. The white solid was filtered off and the crude product mixture was further purified via column chromatography. Retention time (min)=2.490, method [1], MS(ESI) 257.9 (M+H).

後処理

  1. concentrationThe product mixture was concentrated under reduced pressure to one half of its original volumn
  2. filtrationThe white solid was filtered off
  3. customthe crude product mixture was further purified via column chromatography

出典と根拠

ORDレコード
ord-e7d8c773b0a4443084e5a46a84e9f879
出典データセット
uspto-grants-2015_07
特許番号
US09073891B2

反応ノート

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