Methyl iodide → 1-(2-Bromophenylsulfanyl)-2-chloro-4-methoxybenzene

反応式

[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].[Cl:9][C:10]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=1I.NC1C=CC(O)=CC=1Cl.CI>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][C:11]1[CH:12]=[CH:13][C:14]([O:16][CH3:17])=[CH:15][C:10]=1[Cl:9]

参加物

反応物 4

HCID 6328Methyl iodide

HCID 805982-Bromobenzenethiol

HCID 871844-Amino-3-chlorophenol

HCID 180015192-Chloro-1-iodo-4-methoxybenzene

生成物 1

HCID 686829051-(2-Bromophenylsulfanyl)-2-chloro-4-methoxybenzene

実験手順

Prepared from 2-bromo-benzenethiol and 2-chloro-1-iodo-4-methoxy-benzene (prepared from 4-amino-3-chloro-phenol by diazotization according to the general procedure by Tunney and Stille J. Org. Chem. 1987, 52, 748-753 followed by alkylation with methyl iodide according to the general procedure by Uozumi et al. J. Org. Chem. 1993, 58, 1945-1945)