7-Methoxyquinoline → 7-Methoxy-1,2,3,4-tetrahydroquinoline

HRID 1520178ノート

反応式

HRID 1520178 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1>CO.O=[Pt]=O>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][NH:10]2)=[CH:5][CH:4]=1

参加物

4

反応物 1

HCID 786667-Methoxyquinoline

生成物 1

HCID 162443887-Methoxy-1,2,3,4-tetrahydroquinoline収率 73.2%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

To a solution of 7-methoxyquinoline (2.0 g, 12.56 mmol) in methanol (60 ml) was added PtO2 (180 mg, 0.79 mmol). H2 (g) was introduced into above solution and the reaction was stirred overnight at room temperature and then the solids were filtered off. The organics were concentrated in vacuo to give a residue, which was purified by silica gel column chromatography with 3% ethyl acetate in petroleum ether to afford 7-methoxy-1,2,3,4-tetrahydroquinoline as a light yellow oil (1.5 g, 73%).

後処理

  1. additionH2 (g) was introduced into above solution
  2. filtrationthe solids were filtered off
  3. concentrationThe organics were concentrated in vacuo
  4. customto give a residue, which
  5. customwas purified by silica gel column chromatography with 3% ethyl acetate in petroleum ether

出典と根拠

ORDレコード
ord-762f89ecda7745aba699fc390fd16151
出典データセット
uspto-grants-2015_07
特許番号
US09073902B2

反応ノート

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