Sodium Carbonate → 1-((4R,5R)-5-{4-[6-(1-Benzylamino-2,2,2-trifluoro-ethyl)-pyridin-3-yl]-phenyl}-4-fluoromethyl-2,2-dimethyl-oxazolidin-3-yl)-2,2-difluoro-ethanone

反応式

[CH2:1]([NH:8][CH:9]([C:14]1[CH:19]=[CH:18][C:17](Br)=[CH:16][N:15]=1)[C:10]([F:13])([F:12])[F:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:21][CH:22]([F:49])[C:23]([N:25]1[C@H:29]([CH2:30][F:31])[C@@H:28]([C:32]2[CH:37]=[CH:36][C:35](B3OC(C)(C)C(C)(C)O3)=[CH:34][CH:33]=2)[O:27][C:26]1([CH3:48])[CH3:47])=[O:24].C([O-])([O-])=O.[Na+].[Na+]>C1(C)C=CC=CC=1.C(O)C.O.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH2:1]([NH:8][CH:9]([C:14]1[N:15]=[CH:16][C:17]([C:35]2[CH:36]=[CH:37][C:32]([C@H:28]3[O:27][C:26]([CH3:48])([CH3:47])[N:25]([C:23](=[O:24])[CH:22]([F:49])[F:21])[C@H:29]3[CH2:30][F:31])=[CH:33][CH:34]=2)=[CH:18][CH:19]=1)[C:10]([F:13])([F:12])[F:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1