Oxalyl chloride → 3,3-Difluorocyclobutanecarbonyl chloride

HRID 1520861ノート

反応式

HRID 1520861 の反応式
[F:1][C:2]1([F:9])[CH2:5][CH:4]([C:6](O)=[O:7])[CH2:3]1.C(Cl)(=O)C([Cl:13])=O>ClCCl>[F:1][C:2]1([F:9])[CH2:5][CH:4]([C:6]([Cl:13])=[O:7])[CH2:3]1

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 137777893,3-Difluorocyclobutane-1-carboxylic acid

生成物 1

HCID 838550033,3-Difluorocyclobutanecarbonyl chloride収率 50%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3,3-Difluorocyclobutanecarboxylic acid (Parkway Scientific, New York, N.Y., USA) (531 mg, 3.90 mmol) was dissolved in dichloromethane (3.00 mL) and oxalyl chloride (1.02 mL, 11.7 mmol) was added. The solution was stirred at room temperature for 4 h before concentrating in vacuo to provide 3,3-difluorocyclobutanecarbonyl chloride (ca. 50% pure), which was carried on without purification.

後処理

  1. concentrationbefore concentrating in vacuo

出典と根拠

ORDレコード
ord-f895a7f56e714d33a19ab2dcff52f8cb
出典データセット
uspto-grants-2015_07
特許番号
US09073871B2

反応ノート

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