N-bromobutanimide → 6-Bromo-5-chloro-1,2,3,4-tetrahydroquinolin-2-one
反応式
[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][C:6](=[O:12])[NH:7]2.[Br:13]N1C(=O)CCC1=O>CN(C)C=O>[Br:13][C:11]1[C:2]([Cl:1])=[C:3]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:12])[CH2:5][CH2:4]2参加物
4
実験手順
To a stirred solution of 5-chloro-3,4-dihydroquinolin-2(1H)-one (143-4; 0.4 g, 0.022 mol) in N,N-dimethylformamide (10 mL) was added N-bromosuccinimide (0.47 g, 0.0026 mol) portion wise at 0° C. Reaction mixture was allowed to stir at room temperature for 12 h. The reaction mixture was concentrated and diluted with ice cold water (100 mL) with constant stirring and the solid residue was filtered and dried to obtain the title compound. MS (M+1): 259.9.
後処理
- customReaction mixture
- concentrationThe reaction mixture was concentrated
- additiondiluted with ice cold water (100 mL)
- stirringwith constant stirring
- filtrationthe solid residue was filtered
- customdried
出典と根拠
- ORDレコード
- ord-0cb1670d5b674b65b076adebabadc58c
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09073929B2
反応ノート
読み込み中…