N-bromobutanimide → 6-Bromo-2-oxo-1,2,3,4-tetrahydroquinoline-5-carbonitrile

HRID 1521651ノート

反応式

HRID 1521651 の反応式
[O:1]=[C:2]1[CH2:11][CH2:10][C:9]2[C:8]([C:12]#[N:13])=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1.[Br:14]N1C(=O)CCC1=O>CN(C)C=O>[Br:14][C:7]1[CH:6]=[CH:5][C:4]2[NH:3][C:2](=[O:1])[CH2:11][CH2:10][C:9]=2[C:8]=1[C:12]#[N:13]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 665969262-Oxo-1,2,3,4-tetrahydroquinoline-5-carbonitrile

生成物 1

HCID 709774556-Bromo-2-oxo-1,2,3,4-tetrahydroquinoline-5-carbonitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a stirred solution of 2-oxo-1,2,3,4-tetrahydroquinoline-5-carbonitrile (145-1; 1.5 g, 0.0087 mol) in N,N-dimethylformamide (10 mL) was added N-bromosuccinimide (1.8 g, 0.01046 mol) portion wise at 0° C. Reaction mixture was allowed to stir at room temperature for 12 h. It was concentrated and diluted with ice cold water (100 mL) with constant stirring; the solid residue obtained was filtered and dried to obtain the title compound. MS (M+1): 251.2.

後処理

  1. customReaction mixture
  2. concentrationIt was concentrated
  3. additiondiluted with ice cold water (100 mL) with constant stirring
  4. customthe solid residue obtained
  5. filtrationwas filtered
  6. customdried

出典と根拠

ORDレコード
ord-d5c8284b8c6047dc81e845e1645b92ae
出典データセット
uspto-grants-2015_07
特許番号
US09073929B2

反応ノート

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