Acetohydrazide → 7-Bromo-6-cyclopropyl-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline
反応式
[Br:1][C:2]1[C:3]([CH:13]2[CH2:15][CH2:14]2)=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=S)[CH2:6][CH2:5]2.[C:16]([NH:19][NH2:20])(=O)[CH3:17]>C(O)CCC>[Br:1][C:2]1[C:3]([CH:13]2[CH2:15][CH2:14]2)=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[C:16]([CH3:17])=[N:19][N:20]=[C:7]1[CH2:6][CH2:5]2参加物
4
反応条件
- 温度
- 120 °C
実験手順
To a stirred solution of 6-bromo-5-cyclopropyl-3,4-dihydroquinoline-2(1H)-thione (147-7; 0.6 g, 0.00212 mol) in n-butanol (10 mL) was added acetic hydrazide (0.3 g, 0.005 mol). Reaction mass was warmed at 120° C. for 16 h. The reaction mixture was concentrated and directly purified by silica gel column chromatography to obtain title compound. MS (M+1): 305.1.
後処理
- customReaction mass
- concentrationThe reaction mixture was concentrated
- customdirectly purified by silica gel column chromatography
出典と根拠
- ORDレコード
- ord-a4f18ec2101b4e8ba47d9f4909e7c251
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09073929B2
反応ノート
読み込み中…