Water → HCID 59457651、化合物

HRID 1521886ノート

反応式

HRID 1521886 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[N:4][CH:3]=1.[I:9]N1C(=O)CCC1=O.O.C([O-])(O)=O.[Na+]>CS(C)=O>[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[N:4][C:3]=1[I:9]

参加物

6

反応物 4

HCID 962WaterHCID 1184582-Amino-6-ChloropyrazineHCID 120273N-IodosuccinimideHCID 516892Sodium Bicarbonate

生成物 1

HCID 59457651HCID 59457651、化合物

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

A solution of 6-chloropyrazin-2-amine (10.0 g, 77 mmol) in DMSO (100 ml) was treated with 1-iodopyrrolidine-2,5-dione (20.84 g, 93 mmol). The reaction mixture was stirred at RT for 2 days and then added to water (800 ml). The pH was adjusted to pH 8-9 using a sat. NaHCO3 solution and the resulting suspension was filtered, washing with water (×3) and dried under vacuum to afford the titled compound as an orange solid;

後処理

  1. filtrationthe resulting suspension was filtered
  2. washwashing with water (×3)
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-dc75390c9beb4479969b341dc587bfac
出典データセット
uspto-grants-2015_07
特許番号
US09073932B2

反応ノート

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