Acryloyl chloride → (R)-4-(4-(4-((1-acryloylpyrrolidin-3-yl)methoxy)-6-aminopyrimidin-5-yl)phenoxy)benzonitrile

反応式

Cl[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[N:6][C:7]=1Cl.[OH:10][CH2:11][C@@H:12]1[CH2:16][CH2:15][N:14]([C:17]([O:19]C(C)(C)C)=O)[CH2:13]1.CC1(C)C(C)(C)OB([C:32]2[CH:46]=[CH:45][C:35]([O:36][C:37]3[CH:44]=[CH:43][C:40]([C:41]#[N:42])=[CH:39][CH:38]=3)=[CH:34][CH:33]=2)O1.[C:48](Cl)(=O)[CH:49]=C>>[C:17]([N:14]1[CH2:15][CH2:16][C@@H:12]([CH2:11][O:10][C:7]2[C:2]([C:32]3[CH:46]=[CH:45][C:35]([O:36][C:37]4[CH:44]=[CH:43][C:40]([C:41]#[N:42])=[CH:39][CH:38]=4)=[CH:34][CH:33]=3)=[C:3]([NH2:9])[N:4]=[CH:5][N:6]=2)[CH2:13]1)(=[O:19])[CH:48]=[CH2:49]