Trifluoroacetic acid → Trifluoroacetic acid

HRID 1522603ノート

反応式

HRID 1522603 の反応式
[F:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([NH:15][C:16]3[C:17]4[C:18](=[CH:22][N:23](CC5C=CC(OC)=CC=5)[N:24]=4)[N:19]=[CH:20][CH:21]=3)[CH:12]=[CH:11][N:10]=2)=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[C:34]([OH:40])([C:36]([F:39])([F:38])[F:37])=[O:35]>>[F:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([NH:15][C:16]3[C:17]4[C:18](=[CH:22][NH:23][N:24]=4)[N:19]=[CH:20][CH:21]=3)[CH:12]=[CH:11][N:10]=2)=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[C:34]([OH:40])([C:36]([F:39])([F:38])[F:37])=[O:35]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67469529N-(3'-fluoro-6'-methyl-2,2'-bipyridin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

生成物 2

HCID 6422Trifluoroacetic acid収率 92%HCID 178426028HCID 178426028、化合物

反応条件

温度
70 °C

実験手順

N-(3′-Fluoro-6′-methyl-2,2′-bipyridin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine (120 mg, 0.272 mmol) was dissolved in TFA (5 mL) and heated at 70° C. for 3 hours. The reaction mixture was then cooled and evaporated under vacuum to give a residue which was triturated with ether to give the title compound as a TFA salt (80 mg, 92% yield). MS [M+H] found 321.3.

後処理

  1. temperatureThe reaction mixture was then cooled
  2. customevaporated under vacuum
  3. customto give a residue which
  4. customwas triturated with ether

出典と根拠

ORDレコード
ord-fa480b0571a048afb3fc2d5de7194a66
出典データセット
uspto-grants-2015_07
特許番号
US09073918B2

反応ノート

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