Hydrazine hydrate (1:1) → HCID 86724908、化合物

HRID 1523717ノート

反応式

HRID 1523717 の反応式
[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([O:15]C)=O)=[N:5]1)([CH3:3])[CH3:2].O.[NH2:18][NH2:19]>C(O)C>[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([NH:18][NH2:19])=[O:15])=[N:5]1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 10680335HCID 10680335、化合物

生成物 1

HCID 86724908HCID 86724908、化合物収率 6,715.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred solution of methyl 1-isopropyl-1H-indazol-3-yl carboxylate (40.0 grams, 183.5 mmol, obtained in above step) in ethanol at room temperature hydrazine hydrate (130 mL, 2.56 mmol) was added. The reaction mixture was refluxed for 2 hours. The volatiles were removed under reduced pressure and the crude mass was diluted with dichloromethane, washed with water, brine, dried over anhydrous sodium sulphate and the solvent was removed under reduced pressure to obtain the title compound (37.52 grams).

後処理

  1. temperatureThe reaction mixture was refluxed for 2 hours
  2. customThe volatiles were removed under reduced pressure
  3. additionthe crude mass was diluted with dichloromethane
  4. washwashed with water, brine
  5. dry with materialdried over anhydrous sodium sulphate
  6. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-4dfb8bb93adf48499c73af397eb0ecc4
出典データセット
uspto-grants-2015_07
特許番号
US09079894B2

反応ノート

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