Dimethylformamide → 1-Cyclopropylpiperidine-4-carbonyl chloride

HRID 1523719

反応式

HRID 1523719 の反応式
[CH:1]1([N:4]2[CH2:9][CH2:8][CH:7]([C:10]([OH:12])=O)[CH2:6][CH2:5]2)[CH2:3][CH2:2]1.CN(C)C=O.C(Cl)(=O)C([Cl:21])=O>ClCCl>[CH:1]1([N:4]2[CH2:9][CH2:8][CH:7]([C:10]([Cl:21])=[O:12])[CH2:6][CH2:5]2)[CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 162440131-CYCLOPROPylpiPERIDINE-4-CARBOXYLIC ACID

生成物 1

HCID 867249091-Cyclopropylpiperidine-4-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a stirred mixture of 1-cyclopropyl piperidine-4-carboxylic acid (10.0 grams, 48.6 mmol, obtained in above step) in dichloromethane (198 mL) cooled at 0° C. was added dry dimethyl formamide (2 mL) followed by drop wise addition of oxalyl chloride (12.5 mL, 145.8 mmol). The reaction mixture was gradually warmed to room temperature and stirred for 1 hour. The volatiles were removed under reduced pressure and the crude 1-cyclopropyl piperidine-4-carbonyl chloride (11.0 grams). This crude product was used in the next reaction without purification.

後処理

  1. temperatureThe reaction mixture was gradually warmed to room temperature
  2. customThe volatiles were removed under reduced pressure
  3. customThis crude product was used in the next reaction without purification

出典と根拠

ORDレコード
ord-bbe0d73af82945a4809fddec6b1d506f
出典データセット
uspto-grants-2015_07
特許番号
US09079894B2

関連ノート

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