Diisopropylethylamine → tert-Butyl (1-((2-bromophenyl)sulfonyl)piperidin-4-yl)carbamate

HRID 1523762ノート

反応式

HRID 1523762 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](Cl)(=[O:10])=[O:9].[NH:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:14][CH2:13]1.C(N(C(C)C)CC)(C)C>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:12]1[CH2:13][CH2:14][CH:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:23])([CH3:22])[CH3:24])[CH2:16][CH2:17]1)(=[O:10])=[O:9]

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 5204032-Bromobenzenesulfonyl chlorideHCID 7238334-(N-Boc-amino)piperidine

生成物 1

HCID 40175560tert-Butyl (1-((2-bromophenyl)sulfonyl)piperidin-4-yl)carbamate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 2-bromobenzene-1-sulfonyl chloride (50 mg, 0.20 mmol), tert-butyl piperidin-4-ylcarbamate (49 mg, 0.25 mmol), and diisopropylethyl amine (0.101 mL, 0.59 mmol) in CH2Cl2 was stirred for 90 min at rt. The reaction mixture was then concentrated to dryness to give the title compound in quantitative yield. The product was used without further purification.

後処理

  1. concentrationThe reaction mixture was then concentrated to dryness

出典と根拠

ORDレコード
ord-edf99ffd6d2d48e69cf4ddaa2ccdc846
出典データセット
uspto-grants-2015_07
特許番号
US09079866B2

反応ノート

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