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2-[(4-Nitro-phenyl)methyl]-1-(4-fluorophenyl)-2-dimethylamino-1-butanone → 2-[(4-Aminophenyl)methyl]-1-(4-fluorophenyl)-2-dimethylamino-1-butanone

HRID 15246
ノート
印刷プレビュー

反応式

HRID 15246 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([N:23]([CH3:25])[CH3:24])([CH2:21][CH3:22])[C:12]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[O:13])=[CH:6][CH:5]=1)([O-])=O.[H][H]>[Pd].C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([N:23]([CH3:25])[CH3:24])([CH2:21][CH3:22])[C:12]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[O:13])=[CH:6][CH:5]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 686377532-[(4-Nitro-phenyl)methyl]-1-(4-fluorophenyl)-2-dimethylamino-1-butanoneHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 686385232-[(4-Aminophenyl)methyl]-1-(4-fluorophenyl)-2-dimethylamino-1-butanone

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

7.0 g Palladium on charcoal (5%) are added to solution of 69.5 g (0.178 mol) 2-[(4-nitro-phenyl)methyl]-1-(4-fluorophenyl)-2-dimethylamino-1-butanone in 700 ml ethanol in an hydrogenation autoclave. Hydrogen is entered with a continuous increase of pressure to 5 bar at temperature between room temperature and 40° C. After 25 hours no further hydrogen uptake is observed. The catalyst is filtered off and the crude product obtained as yellowish oil after evaporation of the solvent. Thin film chromatography shows a main product and some minor by-products. The crude material is used without further purification in the next reaction step.

後処理

  1. temperaturea continuous increase of pressure to 5 bar at temperature between room temperature and 40° C
  2. filtrationThe catalyst is filtered off

出典と根拠

ORDレコード
ord-c0a59aec5c9b49048cc6d6e49041b7d0
出典データセット
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07732504B2

反応ノート

読み込み中…

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