Acetic Anhydride → N-(3-(2-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)acetamide
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:12]=[C:11]([NH2:13])[N:10]([CH3:14])[N:9]=1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:12]=[C:11]([NH:13][C:15](=[O:17])[CH3:16])[N:10]([CH3:14])[N:9]=1参加物
4
実験手順
To a solution of 3-(2-chlorophenyl)-1-methyl-1H-pyrazol-5-amine (617 mg, 3 mmol) in pyridine (6 mL) was added acetic anhydride (425 μl, 4.5 mmol). The reaction was stirred at room temperature for 16 h. The mixture was concentrated in vacuo. The crude residue was purified by column chromatography (silica gel, gradient 0 to 100% ethyl acetate/isohexane) yielding N-(3-(2-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)acetamide as a solid (526 mg).
後処理
- concentrationThe mixture was concentrated in vacuo
- customThe crude residue was purified by column chromatography (silica gel, gradient 0 to 100% ethyl acetate/isohexane)
出典と根拠
- ORDレコード
- ord-19630ce319d44db0b23aaa711fbefe8b
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09079909B2
反応ノート
読み込み中…