Thionyl Chloride → N-(2-chloroethyl)-N-methyl-octadecyl ammonium chloride

HRID 1525804ノート

反応式

HRID 1525804 の反応式
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][N:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:9]>ClCCCl>[Cl-:3].[Cl:3][CH2:6][CH2:7][NH+:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:9]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 13564486N-(2-hydroxyethyl)-N-methyl-octadecylamine

生成物 1

HCID 86722748N-(2-chloroethyl)-N-methyl-octadecyl ammonium chloride

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒2 回

反応条件

温度
50 °C

実験手順

Thionyl chloride (0.45 mL) was dissolved in 1,2-dichloroethane (3.0 mL). The solution of N-(2-hydroxyethyl)-N-methyl-octadecylamine (1.0 g) in 1,2-dichloroethane (7.0 mL) was added thereto at 0° C., followed by stirring at 50° C. for 30 minutes. The reaction solution was concentrated under reduced pressure and azeotrope was carried out with toluene twice to obtain the title compound (1.2 g) having the following physical property values.

後処理

  1. customat 0° C.
  2. concentrationThe reaction solution was concentrated under reduced pressure and azeotrope

出典と根拠

ORDレコード
ord-ea442a2ce6364d72b993fe7baaff4c19
出典データセット
uspto-grants-2015_07
特許番号
US09085523B2

反応ノート

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