Diisopropylethylamine → HCID 117667157、化合物
反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:31])=[C:6]([CH:30]=1)[O:7][C:8]1[N:9]=[C:10]([NH:21][C:22]2[CH:23]=[N:24][N:25]([CH2:27][CH2:28][OH:29])[CH:26]=2)[C:11]([C:18]([NH2:20])=[O:19])=[N:12][C:13]=1[C:14](O)([CH3:16])[CH3:15].C(N(C(C)C)CC)(C)C>CN1CCCC1=O>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:31])=[C:6]([CH:30]=1)[O:7][C:8]1[N:9]=[C:10]([NH:21][C:22]2[CH:23]=[N:24][N:25]([CH2:27][CH2:28][OH:29])[CH:26]=2)[C:11]([C:18]([NH2:20])=[O:19])=[N:12][C:13]=1[C:14]([CH3:16])=[CH2:15]参加物
4
実験手順
A mixture of 5-(5-amino-2-fluorophenoxy)-3-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}-6-(2-hydroxypropan-2-yl)pyrazine-2-carboxamide (515 mg), diisopropylethylamine (409 μL), and N-methylpyrrolidone (3 mL) was reacted in a microwave reaction device at 200° C. for 4 hours. The mixture was purified by silica gel column chromatography (eluent; chloroform:methanol=98:2-90:10) to obtain 5-(5-amino-2-fluorophenoxy)-3-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}-6-(prop-1-en-2-yl)pyrazine-2-carboxamide (408 mg) as a yellow solid.