Trifluoroacetic acid → 1-(3-methoxybutan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid
反応式
[CH3:1][O:2][CH:3]([CH3:23])[CH:4]([N:6]1[C:10]2=[N:11][CH:12]=[CH:13][CH:14]=[C:9]2[C:8]([C:15]([O:17]C(C)(C)C)=[O:16])=[C:7]1[CH3:22])[CH3:5].FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][O:2][CH:3]([CH3:23])[CH:4]([N:6]1[C:10]2=[N:11][CH:12]=[CH:13][CH:14]=[C:9]2[C:8]([C:15]([OH:17])=[O:16])=[C:7]1[CH3:22])[CH3:5]参加物
4
反応条件
- 温度
- 27 °C
実験手順
To the pre-cooled solution of tert-butyl 1-(3-methoxybutan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (3.0 g, 9.42 mmol) in CH2Cl2 (20 mL) was added trifluoroacetic acid (20 mL) dropwise. The solution was stirred at 27° C. for 1.5 hours. The solvent was removed under vacuum at 27° C. The residue was used for next step without purified. LCMS (M+H+) m/z: calcd 263.30. found 262.9.