Lithium hydroxide, monohydrate → HCID 86673816、化合物

HRID 1527268ノート

反応式

HRID 1527268 の反応式
C[O:2][C:3](=[O:17])[CH2:4][C:5]1[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]2=[C:7]([C:14](=[O:16])[CH3:15])[N:6]=1.O[Li:19].O>C1COCC1.O>[C:14]([C:7]1[N:6]=[C:5]([CH2:4][C:3]([O-:17])=[O:2])[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=12)(=[O:16])[CH3:15].[Li+:19]

参加物

5

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 68283887HCID 68283887、化合物

生成物 1

HCID 86673816HCID 86673816、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of (1-acetyl-imidazo[1,5-a]pyridin-3-yl)-acetic acid methyl ester (1.12 g, 4.82 mmol) in THF (15 mL) and water (7.5 mL) was added LiOH.H2O (202 mg, 4.82 mmol). The reaction was stirred at RT for 5.5 h until completion of the reaction. The mixture was concentrated under reduced pressure and the material thus obtained was used in the next step without further purification: MS (UPLC/MS): 219.2 [M+H]+, 241.2 [M+Na]+, 217.2 [M−H]−; tR (HPLC conditions f): 1.03 min.

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customthe material thus obtained
  3. customwas used in the next step without further purification
  4. custom1.03 min.

出典と根拠

ORDレコード
ord-4f719a47138746469d7ba26284c64fed
出典データセット
uspto-grants-2015_07
特許番号
US09085555B2

反応ノート

読み込み中…