Trifluoroacetic acid → (3-Acetyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid

HRID 1527272ノート

反応式

HRID 1527272 の反応式
C([O:5][C:6](=[O:21])[CH2:7][N:8]1[C:12]2=[CH:13][N:14]=[C:15]([CH3:17])[CH:16]=[C:11]2[C:10]([C:18](=[O:20])[CH3:19])=[N:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:18]([C:10]1[C:11]2[C:12](=[CH:13][N:14]=[C:15]([CH3:17])[CH:16]=2)[N:8]([CH2:7][C:6]([OH:21])=[O:5])[N:9]=1)(=[O:20])[CH3:19]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 68283035(3-Acetyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid tert-butyl ester

生成物 1

HCID 68283539(3-Acetyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of (3-acetyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid tert-butyl ester (126 mg, 0.37 mmol) and TFA (0.171 mL, 2.22 mmol) in CH2Cl2 (5 mL) was stirred at RT for 24 h. Solvents were removed under reduced pressure, Et2O was added and the precipitate was filtered, washed with Et2O and dried under high vacuum. The material thus obtained was used without further purification in the next step. MS (UPLC/MS): 234 [M+H]+, 232 [M−H]−, 465 [2M−H]−; tR (HPLC conditions f): 0.53 min.

後処理

  1. customSolvents were removed under reduced pressure, Et2O
  2. additionwas added
  3. filtrationthe precipitate was filtered
  4. washwashed with Et2O
  5. customdried under high vacuum
  6. customThe material thus obtained
  7. customwas used without further purification in the next step
  8. custom0.53 min.

出典と根拠

ORDレコード
ord-51abe66e203b461bbaac33338cfa7462
出典データセット
uspto-grants-2015_07
特許番号
US09085555B2

反応ノート

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