Trifluoroacetic acid → 1H-Pyrazolo[3,4-c]pyridine-1-acetic acid, 3-(aminocarbonyl)-

HRID 1527291ノート

反応式

HRID 1527291 の反応式
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][N:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:5]=1)(=[O:3])[NH2:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][N:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[NH2:2]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 68284362tert-butyl 2-(3-carbamoyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate

生成物 1

HCID 682831141H-Pyrazolo[3,4-c]pyridine-1-acetic acid, 3-(aminocarbonyl)-

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl 2-(3-carbamoyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate (663 mg, 2.40 mmol) in CH2Cl2 (20 mL) was added TFA (10 mL, 130 mmol), and the resulting mixture was stirred at RT for 6 h. The reaction mixture was concentrated in vacuo, the residual solid was suspended in methanol and volatiles were removed again in vacuo to give the title compound.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customvolatiles were removed again in vacuo

出典と根拠

ORDレコード
ord-8cb66e40a0344627946f221bcf5fc74e
出典データセット
uspto-grants-2015_07
特許番号
US09085555B2

反応ノート

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