Trifluoroacetic acid → (2S,4R)-2-Azidomethyl-4-fluoro-pyrrolidine

HRID 1527382ノート

反応式

HRID 1527382 の反応式
C(OC([N:8]1[CH2:12][C@H:11]([F:13])[CH2:10][C@H:9]1[CH2:14][N:15]=[N+:16]=[N-:17])=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:15]([CH2:14][C@@H:9]1[CH2:10][C@@H:11]([F:13])[CH2:12][NH:8]1)=[N+:16]=[N-:17]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86673832HCID 86673832、化合物

生成物 1

HCID 86673833(2S,4R)-2-Azidomethyl-4-fluoro-pyrrolidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (2S,4R)-2-azidomethyl-4-fluoro-pyrrolidine-1-carboxylic acid tert-butyl ester (600 mg, 2.45 mmol) in CH2Cl2 (2.5 mL) was added TFA (1.88 mL, 24.6 mmol) and the solution was stirred at RT for 2 h. CH2Cl2 was concentrated and the crude was dried under high vacuum to give the desired material which was used without further purification in the next step.

後処理

  1. concentrationCH2Cl2 was concentrated
  2. customthe crude was dried under high vacuum

出典と根拠

ORDレコード
ord-68646736dd584fda86226b06b63909c7
出典データセット
uspto-grants-2015_07
特許番号
US09085555B2

反応ノート

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