(2-Chloro-3-Fluoropyridin-4-Yl)Methanol → 2-Chloro-3-fluoro-4-formylpyridine
反応式
[Cl:1][C:2]1[C:7]([F:8])=[C:6]([CH2:9][OH:10])[CH:5]=[CH:4][N:3]=1>C(Cl)Cl.O=[Mn]=O>[Cl:1][C:2]1[C:7]([F:8])=[C:6]([CH:9]=[O:10])[CH:5]=[CH:4][N:3]=1参加物
4
実験手順
A mixture of (2-chloro-3-fluoro-pyridin-4-yl)-methanol (0.9 g, 5.76 mmol) and activated MnO2 (5.76 g, 66.2 mmol) in CH2Cl2 was stirred at RT overnight. The solid was filtered off and washed with CH2Cl2, and the filtrate was concentrated under mildly reduced pressure to afford the title compound as a colorless liquid. MS (LC/MS): 191.0 [M+MeOH]+; tR (HPLC conditions b): 2.02 min.
後処理
- filtrationThe solid was filtered off
- washwashed with CH2Cl2
- concentrationthe filtrate was concentrated under mildly reduced pressure
出典と根拠
- ORDレコード
- ord-34c2d5f4d1b641f8a7b5b970503f2173
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09085555B2
反応ノート
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