[3-Fluoro-2-(trifluoromethyl)pyridin-4-yl]methanol → 3-Fluoro-2-(trifluoromethyl)pyridine-4-carbaldehyde

HRID 1527467ノート

反応式

HRID 1527467 の反応式
[F:1][C:2]1[C:3]([C:10]([F:13])([F:12])[F:11])=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8][OH:9]>C(Cl)Cl.O=[Mn]=O>[F:1][C:2]1[C:3]([C:10]([F:12])([F:13])[F:11])=[N:4][CH:5]=[CH:6][C:7]=1[CH:8]=[O:9]

参加物

4

反応物 1

HCID 68283421[3-Fluoro-2-(trifluoromethyl)pyridin-4-yl]methanol

生成物 1

HCID 866738643-Fluoro-2-(trifluoromethyl)pyridine-4-carbaldehyde

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of (3-fluoro-2-trifluoromethyl-pyridin-4-yl)-methanol (0.620 g, 3.18 mmol) and activated MnO2 (3.20 g, 36.5 mmol) in CH2Cl2 was stirred at RT overnight. The solid was filtered off, washed with CH2Cl2, and the filtrate was concentrated under mildly reduced pressure to afford the title compound as a yellow liquid. MS (LC/MS): 212.0 [M+NH4]+, 226.0 [M+MeOH]+. tR (HPLC conditions c): 3.26 min.

後処理

  1. filtrationThe solid was filtered off
  2. washwashed with CH2Cl2
  3. concentrationthe filtrate was concentrated under mildly reduced pressure

出典と根拠

ORDレコード
ord-8b86983cf75a440fb942803377df3f4b
出典データセット
uspto-grants-2015_07
特許番号
US09085555B2

反応ノート

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