1,1-Dimethylethyl 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]propanoate → 3-(2-Aminoethoxy)propanoic acid

HRID 1527651ノート

反応式

HRID 1527651 の反応式
C([O:5][C:6](=[O:20])[CH2:7][CH2:8][O:9][CH2:10][CH2:11][NH:12]C(OC(C)(C)C)=O)(C)(C)C>FC(F)(F)C(O)=O>[NH2:12][CH2:11][CH2:10][O:9][CH2:8][CH2:7][C:6]([OH:20])=[O:5]

参加物

3

反応物 1

HCID 894222391,1-Dimethylethyl 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]propanoate

生成物 1

HCID 144623893-(2-Aminoethoxy)propanoic acid

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

3-(2-tert-Butoxycarbonylamino-ethoxy)-propionic acid tert-butyl ester (10 g) was dissolved in a 1:1 trifluoroacetic acid (TFA)/DCM mixture (100 mL) and stirred at room temperature for 1 h. The solvent was then removed on a rotary evaporator and the resulting oil was re-dissolved in DCM and concentrated to dryness. This process was repeated until minimal TFA scent remained before the oil was dried on high vacuum for several hours.

後処理

  1. customThe solvent was then removed on a rotary evaporator
  2. dissolutionthe resulting oil was re-dissolved in DCM
  3. concentrationconcentrated to dryness
  4. customwas dried on high vacuum for several hours

出典と根拠

ORDレコード
ord-79c3a0141fc3499580561f46adf7e903
出典データセット
uspto-grants-2015_07
特許番号
US09089611B2

反応ノート

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