Diisopropyl Ether → Ethyl (E)-3-(3-bromo-1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoate

反応式

[Br:1][C:2]1[C:3]([CH:16]=O)=[C:4]([O:14][CH3:15])[C:5]2[C:10]([C:11]=1[O:12][CH3:13])=[CH:9][CH:8]=[CH:7][CH:6]=2.COC1C2C(=CC=CC=2)C(OC)=CC=1/[CH:32]=[C:33](\C)/[C:34]([O:36][CH2:37][CH3:38])=[O:35].O(C(C)C)C(C)C>>[Br:1][C:2]1[C:3](/[CH:16]=[C:33](\[CH3:32])/[C:34]([O:36][CH2:37][CH3:38])=[O:35])=[C:4]([O:14][CH3:15])[C:5]2[C:10]([C:11]=1[O:12][CH3:13])=[CH:9][CH:8]=[CH:7][CH:6]=2

参加物

反応物 3

HCID 7914Diisopropyl Ether

HCID 112086483-Bromo-1,4-dimethoxy-2-naphthaldehyde

HCID 46180044HCID 46180044、化合物

生成物 1

HCID 46180107Ethyl (E)-3-(3-bromo-1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoate

実験手順

Compound 98e was prepared from 38 (0.515 g, 1.75 mmol) as described above for 28a to give 0.373 g (0.984 mmol, 56%) of the product as a white solid following flash chromatography (1:19 i-Pr2O:hexanes) and recrystallization from Et2O/hexanes. (0.314 g E; 0.059 g Z)

後処理

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出典と根拠

ORDレコード: ord-83b9d314dd2e449789ab4e0d94cfa6b4
出典データセット: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09089605B2

反応ノート

読み込み中…