Water → HCID 86720865、化合物
反応式
CCN(C(C)C)C(C)C.Br[C:11]1[C:16]([NH2:17])=[CH:15][N:14]=[CH:13][N:12]=1.[SH:18][CH2:19][CH2:20][CH2:21][OH:22].O>O1CCOCC1>[NH2:17][C:16]1[C:11]([S:18][CH2:19][CH2:20][CH2:21][OH:22])=[N:12][CH:13]=[N:14][CH:15]=1参加物
6
反応条件
- 温度
- 50 °C
実験手順
DIEA (1.11 g, 8.61 mmol) was added to a solution of 4-bromopyrimidin-5-amine (A) (1.0 g, 5.74 mmol) and 3-mercaptopropan-1-ol (35B1) (0.53 g, 5.74 mmol) in dioxane (5 mL). The reaction mixture was heated to 50° C. under nitrogen and stirred for 30 min. The LC/MS spectrum showed that the reaction had completed. Water (50 mL) was added and a solid precipitated. The off white solid product (35C1) (913 mg, 4.93 mmol) was obtained after filtration and air drying at 25° C.
後処理
- customa solid precipitated
- customThe off white solid product (35C1) (913 mg, 4.93 mmol) was obtained
- filtrationafter filtration and air
- customdrying at 25° C.
出典と根拠
- ORDレコード
- ord-d68f503074924d43b6c44e8f7bd57d43
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09090594B2
反応ノート
読み込み中…