Aluminium lithium hydride → (1-(4-Bromophenyl)cyclopropyl)methanol
反応式
C([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[Br:15][C:12]1[CH:11]=[CH:10][C:9]([C:6]2([CH2:4][OH:3])[CH2:7][CH2:8]2)=[CH:14][CH:13]=1参加物
4
実験手順
To 1-(4-bromo-phenyl)-cyclopropanecarboxylic acid ethyl ester (10.0 g, 37.2 mmol) in THF (100 mL) at 0° C. was added lithium aluminum hydride (2.11 g, 55.7 mmol) and the reaction was stirred for 1 hour at room temperature. The mixture was quenched with H2O (2 mL), followed by 4 N aqueous NaOH (2 mL) and additional H2O (6 mL). After stirring for 15 minutes, the solid precipitate was removed by filtration and the filtrate was concentrated and dried to give the title compound.
後処理
- customThe mixture was quenched with H2O (2 mL)
- stirringAfter stirring for 15 minutes
- customthe solid precipitate was removed by filtration
- concentrationthe filtrate was concentrated
- customdried
出典と根拠
- ORDレコード
- ord-7ac50cbef6494b6b8fe5bb383f4cff32
- 出典データセット
- uspto-grants-2015_07
- 特許番号
- US09090573B2
反応ノート
読み込み中…