Methanol → 1-[(4-Bromophenyl)methyl]cyclopropanecarboxylic acid

HRID 1529036ノート

反応式

HRID 1529036 の反応式
[Br:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][C:7]2([C:10]#N)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[OH-:14].[Na+].C[OH:17]>>[Br:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][C:7]2([C:10]([OH:17])=[O:14])[CH2:9][CH2:8]2)=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 66578489HCID 66578489、化合物

生成物 1

HCID 658114561-[(4-Bromophenyl)methyl]cyclopropanecarboxylic acid

実験手順

1-(4-Bromo-benzyl)-cyclopropanecarbonitrile (from the previous step) was dissolved in MeOH and NaOH (35% aq.) and the reaction was heated to reflux for 8 hours. After cooling the reaction was submitted to standard acid-base workup to afford the title compound.

後処理

  1. temperatureto reflux for 8 hours
  2. temperatureAfter cooling the reaction

出典と根拠

ORDレコード
ord-d6fa3e0e3dc248e0966074ae4b52bb24
出典データセット
uspto-grants-2015_07
特許番号
US09090573B2

反応ノート

読み込み中…