Tributylstannane → 4-Chloro-2-(tributylstannyl)pyrimidine

HRID 1529303ノート

反応式

HRID 1529303 の反応式
[Li+].CC([N-]C(C)C)C.[CH3:9][CH2:10][CH2:11][CH2:12][SnH:13]([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:14][CH2:15][CH2:16][CH3:17].[Cl:22][C:23]1[N:28]=[C:27]([Cl:29])[CH:26]=[CH:25][N:24]=1>C1COCC1>[Cl:22][C:23]1[N:28]=[C:27]([Sn:13]([CH2:12][CH2:11][CH2:10][CH3:9])([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:14][CH2:15][CH2:16][CH3:17])[CH:26]=[CH:25][N:24]=1.[Cl:29][C:27]1[CH:26]=[CH:25][N:24]=[C:23]([Sn:13]([CH2:12][CH2:11][CH2:10][CH3:9])([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:14][CH2:15][CH2:16][CH3:17])[N:28]=1

参加物

6

反応物 3

HCID 5948TributylstannaneHCID 775312,4-DichloropyrimidineHCID 2724682Lithium diisopropylamide

生成物 2

HCID 149763044-Chloro-2-(tributylstannyl)pyrimidine収率 24%HCID 468399532-Chloro-4-(tributylstannyl)pyrimidine収率 5.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
-78 °C

実験手順

To a mixture of THF (300 mL) and LDA (100 mL, 20.1 mmol) at −20° C. was added Bu3SnH (50 mL, 17.4 mmol) dropwise and stirred for 15 min. The reaction mixture was cooled to −78° C. and treated with 2,4-dichloro pyrimidine (20 g, 134 mmol) portionwise. The reaction mixture was stirred at −78° C. for 5 h with constant stirring under argon atmosphere. The cooling bath was removed and the reaction mixture was warmed up to 0° C. within 30 min. The resulting mixture was poured into 10% NH4Cl aqueous solution, and extracted the compound with Et2O. The organic layer was washed with brine, dried with Na2SO4, filtered, and evaporated. The residue was purified by column chromatography (1% EtOAc: 99% n-Hexane) to obtain 2-chloro-4-tributylstannanyl-pyrimidine 20a (3 g, 5.5% yield) as a pale yellow color syrup and 4-chloro-2-tributylstannanyl-pyrimidine 24a (13 g, 24% yield) as a pale yellow color syrup. Compound 24a: MS (ESI, pos. ion) m/z: 405.3 (M+1).

後処理

  1. stirringThe reaction mixture was stirred at −78° C. for 5 h
  2. stirringwith constant stirring under argon atmosphere
  3. customThe cooling bath was removed
  4. temperaturethe reaction mixture was warmed up to 0° C. within 30 min
  5. additionThe resulting mixture was poured into 10% NH4Cl aqueous solution
  6. extractionextracted the compound with Et2O
  7. washThe organic layer was washed with brine
  8. dry with materialdried with Na2SO4
  9. filtrationfiltered
  10. customevaporated
  11. customThe residue was purified by column chromatography (1% EtOAc: 99% n-Hexane)

出典と根拠

ORDレコード
ord-3a2fefad8ea3476aa60d3c63f1c7fcd5
出典データセット
uspto-grants-2015_07
特許番号
US09090593B2

反応ノート

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